| Episode | Name | Airdate |
|---|
| S04E01 | Hugh Jackman, Shay Mitchell | Oct 5, 2015 |
| S04E02 | Sarah Michelle Gellar, Shaquille O'Neal | Oct 6, 2015 |
| S04E03 | Rooney Mara, Gina Rodriguez, Abby Wambach | Oct 7, 2015 |
| S04E04 | Seth Rogen, Billy Eichner, the Vamps | Oct 8, 2015 |
| S04E05 | Kate Winslet, Ted Danson, Sara Bareilles | Oct 9, 2015 |
| S04E06 | Clive Owen, Jussie Smollett, Ronda Rousey | Oct 12, 2015 |
| S04E07 | Jessica Chastain, Gabrielle Union, guest co-host Ciara | Oct 13, 2015 |
| S04E08 | Tom Hanks, Carey Mulligan | Oct 14, 2015 |
| S04E09 | Tom Selleck, Jennifer Carpenter, Andra Day | Oct 15, 2015 |
| S04E10 | Jack Black, Amy Brenneman | Oct 16, 2015 |
| S04E11 | Jimmy Kimmel, Robin Thicke, Daniel Boulud | Oct 19, 2015 |
| S04E12 | Vin Diesel, Amanda Peet, Alfred Portale | Oct 20, 2015 |
| S04E13 | Michael J. Fox, Sarah Paulson, Alex Guarnaschelli | Oct 21, 2015 |
| S04E14 | Patricia Heaton, Ed Westwick, Marc Forgione | Oct 22, 2015 |
| S04E15 | Kate Hudson, Kat Dennings, Eric Ripert | Oct 23, 2015 |
| S04E16 | Stanley Tucci, Wesley Snipes | Oct 26, 2015 |
| S04E17 | Adam Levine, Mike Tyson | Oct 27, 2015 |
| S04E18 | Seth Meyers, Stephen Moyer, Andrea Bocelli | Oct 28, 2015 |
| S04E19 | Sandra Bullock, Jamie Oliver | Oct 29, 2015 |
| S04E20 | LIVE's Best Halloween Show Ever: Nightmare on 67th Street | Oct 30, 2015 |
| S04E21 | Allison Janney, Steve Martin & Edie Brickell, Andrea Arden | Nov 2, 2015 |
| S04E22 | Gwen Stefani, Ralph Fiennes, Dr. Jennifer Jellison | Nov 3, 2015 |
| S04E23 | Andy Cohen, Bryan Adams, Dr. Karen Halligan | Nov 4, 2015 |
| S04E24 | Daniel Craig, Harry Connick Jr., Bernadette Peters | Nov 5, 2015 |
| S04E25 | Christoph Waltz, Antonio Banderas | Nov 6, 2015 |
| S04E26 | Daniel Radcliffe; Bryshere Gray; Seal | Nov 9, 2015 |
| S04E27 | Jennifer Connelly, Rainn Wilson, James Bay | Nov 10, 2015 |
| S04E28 | Viola Davis, James McAvoy | Nov 11, 2015 |
| S04E29 | Ethan Hawke, Emma Roberts, Tim McGraw | Nov 12, 2015 |
| S04E30 | John Stamos, Dr. Melina Jampolis explains the Doctor on Demand Diet, A Great Big World | Nov 13, 2015 |
| S04E31 | Blake Shelton, Kyle Chandler, Kelly and Michael taste-test fast-food fries | Nov 16, 2015 |
| S04E32 | Cate Blanchett, Burt Reynolds, Katie Brown teaches Kelly and Michael how to wrap gifts | Nov 17, 2015 |
| S04E33 | Liam Hemsworth, CeeLo Green, Kelly and Michael host the entire show while dressed in their pajamas | Nov 18, 2015 |
| S04E34 | Hillary Clinton, Josh Hutcherson, musical duo A Great Big World teaches Kelly and Michael how to write a song | Nov 19, 2015 |
| S04E35 | Elizabeth Banks, Shawn Mendes, Kelly and Michael stomp grapes | Nov 20, 2015 |
| S04E36 | Pharrell Williams, Jena Malone, Holly Holm | Nov 23, 2015 |
| S04E37 | Jennifer Hudson, Josh Groban | Nov 24, 2015 |
| S04E38 | Mariah Carey, Melissa Benoist, Kyle Busch | Nov 25, 2015 |
| S04E39 | Jesse Tyler Ferguson, Beth Behrs, Joss Stone, Carly Simon | Nov 27, 2015 |
| S04E40 | Michael Chiklis, Uzo Aduba, Michelle Tan | Nov 30, 2015 |
| S04E41 | Harrison Ford, Frank Grillo, Monica Mangin | Dec 1, 2015 |
| S04E42 | Mary J. Blige, Faith Ford, Ted McGinley, Lance Ulanoff | Dec 2, 2015 |
| S04E43 | Carrie Fisher, Chris Byrne | Dec 3, 2015 |
| S04E44 | Justin Theroux, Lawrence Zarian | Dec 4, 2015 |
| S04E45 | Chris Hemsworth, Billie Lourd | Dec 7, 2015 |
| S04E46 | Maya Rudolph, Daisy Ridley, Gigi Hadid | Dec 8, 2015 |
| S04E47 | Donald Trump, John Boyega, Chris Isaak | Dec 9, 2015 |
| S04E48 | Amy Poehler, Mandy Patinkin | Dec 10, 2015 |
| S04E49 | Lupita Nyong'o, Kirsten Dunst | Dec 11, 2015 |
| S04E50 | Mark Wahlberg, Gwendoline Christie, Sara Bareilles | Dec 14, 2015 |
| S04E51 | Jennifer Lawrence, Raymond Crowe | Dec 15, 2015 |
| S04E52 | Will Ferrell, Bella Thorne | Dec 16, 2015 |
| S04E53 | Kurt Russell, Daya | Dec 17, 2015 |
| S04E54 | Kurt Russell, Daya | Dec 18, 2015 |
| S04E55 | Bruce Willis, Kevin Zraly, a performance from "Disney On Ice: 100 Years Of Magic" | Dec 21, 2015 |
| S04E56 | Channing Tatum, Cee-Lo Green, the Rockettes | Dec 22, 2015 |
| S04E57 | Adam Levine, Jack Black, Ronda Rousey, Trevor Noah | Dec 23, 2015 |
| S04E58 | Carol Burnett, Ariana Grande, Jussie Smollett, Stephen Curry | Dec 24, 2015 |
| S04E59 | Samuel L. Jackson, Ben Higgins, Miss Universe Pia Wurtzbach | Jan 4, 2016 |
| S04E60 | Ryan Seacrest, Jennifer Jason Leigh | Jan 5, 2016 |
| S04E61 | Felicity Huffman, Damian Lewis, James Oseland | Jan 6, 2016 |
| S04E62 | Emmy Rossum, Shaun T | Jan 7, 2016 |
| S04E63 | Tyler Perry, Dr. Ian Smith | Jan 8, 2016 |
| S04E64 | John Krasinski, Heather Graham | Jan 11, 2016 |
| S04E65 | Ray Liotta, Lucy Hale | Jan 12, 2016 |
| S04E66 | Ice Cube, Brie Larson, Jason Jacobson | Jan 13, 2016 |
| S04E67 | Olivia Munn | Jan 14, 2016 |
| S04E68 | Khloe Kardashian, desert animals from the San Diego Zoo | Jan 15, 2016 |
| S04E84 | Katie Holmes, Vanna White | Feb 8, 2016 |
| S04E85 | Ryan Reynolds, Fred Savage | Feb 9, 2016 |
| S04E86 | Ben Stiller, Bob Odenkirk | Feb 10, 2016 |
| S04E87 | Penelope Cruz, Bobby Cannavale, Maddie & Tae | Feb 11, 2016 |
| S04E88 | A celebration of Kelly's 15th anniversary as co-host | Feb 12, 2016 |
| S04E89 | Allison Williams, Danai Gurira, Rick Springfield | Feb 15, 2016 |
| S04E90 | Lena Dunham, Jeff Probst | Feb 16, 2016 |
| S04E91 | Anthony Anderson, Derek Hough, Lance Ulanoff | Feb 17, 2016 |
| S04E92 | Kiefer Sutherland, Travis Fimmel, Jazmine Sullivan | Feb 18, 2016 |
| S04E93 | Jeremy Irons, Lori Loughlin, Chris Byrne | Feb 19, 2016 |
| S04E154 | Chris O'Donnell, Cedric the Entertainer, Trent Harmon | Apr 11, 2016 |
| S04E155 | Gwyneth Paltrow, Jennifer Arnold and Bill Klein, La'Porsha Renae | Apr 12, 2016 |
| S04E156 | Kevin Costner, Ken Jeong, Dalton Rapattoni | Apr 13, 2016 |
| S04E157 | Lupita Nyong'o, Regina Hall | Apr 14, 2016 |
| S04E158 | Common, Saoirse Ronan | Apr 15, 2016 |
| S04E159 | Katharine McPhee, Terry Crews, Amy E. Goodman | Apr 18, 2016 |
| S04E160 | Jason Bateman, Dr. Melinda Jampolis | Apr 19, 2016 |
| S04E161 | Von Miller, Witney Carson, Dr. Taz Bhatia | Apr 20, 2016 |
| S04E162 | Daniel Dae Kim | Apr 21, 2016 |
| S04E163 | Julia Louis-Dreyfus, Dr. David Agus | Apr 22, 2016 |
| S04E164 | Guest Co-Hostess Shay Mitchell, Donnie Wahlberg, Tim Daly | Apr 25, 2016 |
| S04E165 | Bellamy Young, Jaimie Alexander, Jackie Evancho | Apr 26, 2016 |
| S04E166 | Ricky Gervais, Josh Hartnett | Apr 27, 2016 |
| S04E167 | Kate Hudson, Keegan-Michael Key, Peter Gros | Apr 28, 2016 |
| S04E168 | Adam Levine, Jordan Peele | Apr 29, 2016 |
| S04E169 | Adrien Brody, Chadwick Boseman, Ruth B | May 2, 2016 |
| S04E170 | Lucy Liu, Morris Chestnut | May 3, 2016 |
| S04E171 | Jeremy Renner, Carrie Ann Inaba | May 4, 2016 |
| S04E172 | Robert Downey Jr., Jason Derulo, Marcela Valladoid | May 5, 2016 |
| S04E173 | Anthony Mackie | May 6, 2016 |
| S04E174 | Jodie Foster, Megyn Kelly | May 9, 2016 |
| S04E175 | Jessica Lange, Laura Bush, Jenna Bush Hager | May 10, 2016 |
| S04E176 | Chelsea Handler, Lana Parrilla | May 11, 2016 |
| S04E177 | Kate Beckinsale, Joe Morton, Kelsea Ballerini | May 12, 2016 |
| S04E178 | Matt Bomer, Carmelo Anthony | May 13, 2016 |
